Good news! Another stem cell clinical research project approved by the National Health Commission

“Regenerative medicine technology” represented by stem cell technology is the “third medical revolution” after drug treatment and surgical treatment. Stem cells can differentiate and form any tissue in the body, and can self-replicate to produce more stem cells. They have become a key development area at the forefront of international medicine in recent years.

Such advanced scientific research is actually around us.

 

Good news! Another stem cell project passed the filing
On October 20, 2021, the “Prospective, Randomized, Controlled Clinical Study of Human Umbilical Cord Mesenchymal Stem Cell Injection for the Treatment of Diabetic Foot Wounds” applied by President Jin Peisheng of the Affiliated Hospital of Xuzhou Medical University and his team successfully passed the National Health Commission’s filing and approval. This is the first approved stem cell treatment of diabetic foot research project in the country! At present, all preparations are in place, and it is planned to recruit 60 diabetic foot subjects to receive umbilical cord mesenchymal stem cell treatment for free.

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Stimulates tissue cell regeneration and accelerates wound healing – expected to overcome diabetic foot
In recent years, there have been many research reports on the use of stem cell transplantation to treat cerebral ischemia, myocardial infarction, liver cirrhosis and other diseases, and the good therapeutic effects have attracted much attention from patients. But for most people, umbilical cord mesenchymal stem cells are still an unfamiliar term. So, What are umbilical cord mesenchymal stem cells, and what do they have to do with us people?

Every human being gradually develops from a fertilized egg of about 0.5 mm into a complicated human body composed of about 60 trillion and more than 200 types of cells. About 150 million red blood cells die every day, and 30,000 skin cells die every minute. For adults, bones are renewed every 7-10 years, which require stem cells to differentiate into new cells for replenishment. It can be said that our growth, development and metabolism can only proceed normally because of the existence of stem cells.

Stem cells are more important in the treatment of diseases. Human birth, old age, illness and death are a natural law. Diseases often start from damage to individual organs under the influence of specific causes and gradually expand to lesions in multiple organs, leading to failure or loss of function of multiple organs. The essence of stem cell therapy is to provide seed cells for damaged organs, improve the body’s repair ability, improve the local microenvironment, and accelerate tissue healing. Many diseases that currently have no effective treatment options are expected to be solved through stem cell therapy in the future.

In this study of stem cell treatment for diabetic foot reported by Xu Medical Affiliated Hospital, patients were injected with umbilical cord mesenchymal stem cells, which are mesenchymal stem cells isolated and cultured from newborn umbilical cord tissue. font-size: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline;”>With many advantages such as abundant sources, easy acquisition, large number of cells, not easy to be contaminated, low immunogenicity, strong proliferation ability and no ethical restrictions, it is currently one of the most ideal sources of stem cells.

Dr. Li Qiang, Department of Plastic Surgery, Xu Medical Affiliated Hospital, introduced, baseline;”>Umbilical cord mesenchymal stem cells are neonatal stem cells with powerful secretory functions. They can produce a variety of growth factors, cytokines and exosomes, improve the body’s ability to resist free radicals, promote angiogenesis and cell proliferation and differentiation, inhibit inflammatory reactions, regulate cell adhesion and migration functions, stimulate tissue cell regeneration, and accelerate wound healing and tissue remodeling.

Before applying, Xu Medical Affiliated Hospital has conducted sufficient preclinical research to verify the effectiveness and safety of umbilical cord stem cells from all aspects and try to ensure the health of the subjects.

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Successfully passed the National Health Commission’s filing and approval

Dean Jin Peisheng said that stem cell technology is the biotechnology with the most development prospects and potential in this century. The 21st century will be the century of life science and technology represented by biotechnology, and is most likely to form new breakthroughs in the medical field.

Because of this, Stem cell research has gone beyond the scope of pure basic research and has risen to the strategic level of national development. It has become a major scientific proposition that governments of all countries pay close attention to. In order to compete for strategic heights, countries have spent huge sums of money and provided strong policy support, hoping to be the first to master the key technologies of stem cell therapy and create huge economic and social benefits.

According to Zhang Aijun, director of the plastic surgery department of Xu Medical Affiliated Hospital, there are currently more than 100 million diabetic patients in my country, and 15% of them will suffer from blood vessel and nerve damage caused by high sugar, resulting in poor blood supply and healing disorders in the lower limbs, forming diabetic foot. At present, diabetic foot has become a disease that seriously endangers the health of our people, with the total number of patients exceeding 15 million. According to statistics, every 30 seconds in the world, a patient suffers an amputation due to diabetic foot.

It is reported that my country is at the forefront of basic research related to stem cells in the world, but lags behind countries such as Europe and the United States in terms of translation of results and clinical application. In March 2016, the National Health and Family Planning Commission and the Food and Drug Administration jointly established the Stem Cell Clinical Research Expert Committee to initiate stem cell clinical research registration work. As of now, there are 111 stem cell clinical research registration institutions and 101 registered projects in my country.